# The axolotl limb blastema: cellular and molecular mechanisms driving blastema formation and limb regeneration in tetrapods **Authors:** David M. Gardiner **Published:** 2015 **Link:** [PMC4895312](https://pmc.ncbi.nlm.nih.gov/articles/PMC4895312/) The **axolotl** is one of the few animals that can fully regrow its limbs, even as an adult. When it gets injured, it forms a group of special cells called the **blastema**. These cells help rebuild the missing part, including bones, muscles, and skin. Key points: - **Wound Healing:** Right after injury, the axolotl’s body starts preparing for regeneration. - **Blastema Formation:** Special interactions between nerves and skin cells trigger the growth of the blastema. - **Patterning:** Cells in the blastema know where to grow based on their original position in the limb. - **Cell Types:** Different cells contribute to the regrowth process, some setting the shape and others supporting the growth. - **Human Applications:** Scientists believe studying the axolotl can help us learn how to regenerate human tissues in the future. The axolotl’s unique ability to regrow body parts could inspire new medical treatments for humans. Related [[What is it?]]